Generation antibiotic for oral masteron 100 administration. Effective bactericidal (violates the synthesis of cell walls of microorganisms). It has a broad spectrum antimicrobial activity that includes various aerobic and anaerobic gram-positive and gram-negative microorganisms including.upper and lower respiratory tract infections (pharyngitis, tonsillitis, sinusitis, acute bronchitis, exacerbation of chronic bronchitis)otitis media,Urinary tract masteron 100 infections (uncomplicated)uncomplicated gonorrhea of the urethra and cervix.
Advanced age, renal failure, colitis (in history).
Pregnancy and lactation
In pregnancy, the use of the drug is possible only., When the intended benefits to the mother outweighs the potential risk to the fetus. If necessary, use during lactation should stop breastfeeding.
DOSAGE AND ADMINISTRATION
. Inside For children over 12 years weighing more than 50 kg and adults, the average daily dose is 400 mg once daily (or 200 mg 2 times a day). In uncomplicated gonorrhea of the urethra and cervix – 400 mg . once children under the age of 12 years is prescribed at a dose of 8 mg / kg, 1 time per day or 4 mg / kg, 2 times a day (every 12 hours). For children aged 5-11 years, the daily dose of a suspension – 6-10 ml, aged 2-4 years – 5 ml, aged b months to 1 year – 2.5-4 mL. The average duration of the treatment – 10.7 days. In diseases caused of Streptococcus pyogenes , treatment should not be less than 10 days.If the kidney function the dose adjusted according to creatinine clearance (CC) in the blood serum: with CC 21-60 ml / min or in patients on hemodialysis , the daily dose should be reduced by 25%; QC at 20 ml / min or less and in patients undergoing peritoneal dialysis, the daily dose should be reduced by 2 times. A method for preparing the suspension . Turn the bottle and shake powder. The vial was added about half (17 ml), the required volume (34 ml), cooled to room temperature boiled water, capped, shaken thoroughly until a homogeneous suspension. Then add the cooled boiled water to the mark (arrow) on the label, close lid, carefully shaken until a homogeneous suspension. Allow to stand for 5 minutes before use prepared suspension stirred well. Use within 14 days after preparation.
Side effect Allergic reactions : rash, skin redness, itching, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome). From the digestive system : diarrhea, nausea, vomiting, stomatitis , constipation, abdominal pain, pseudomembranous enterocolitis, dysbiosis, cholestasis, cholestatic jaundice. From the nervous system : headache, dizziness, ringing in the ears. From the urogenital system : vaginitis, candidiasis, itching in the genital area. From the urinary system : renal failure masteron 100, interstitial nephritis. From the side of hematopoiesis : pancytopenia, leukopenia, neutropenia, thrombocytopenia, agranulocytosis, aplastic anemia, hemolytic anemia, bleeding. From the laboratory parameters : eosinophilia, increased activity of “liver” transaminases and alkaline phosphatase, hyperbilirubinemia, increase of urea nitrogen, hypercreatininemia, increased prothrombin time. Other : In the development of hypovitaminosis, shortness of breath.
Overdose Symptoms : increased risk of adverse reactions. Treatment : t. To specific antidote does not exist, it is shown gastric lavage, symptomatic and supportive therapy, including the use of corticosteroids, fluid resuscitation, mechanical ventilation.. The procedure of peritoneal dialysis and has no substantial effect on the concentration in the blood plasma of cefixime respectively hemo or peritoneal masteron 100 dialysis is not efficient.
INTERACTION WITH OTHER DRUG
Cefixime reduces prothrombin index, increases the effects of anticoagulants. Increases in serum carbamazepine. Blockers tubular secretion (including allopurinol, diuretics) cefixime delayed excretion by the kidneys, which can lead to increased toxicity. Antacids containing aluminum or magnesium hydroxide, slow absorption of the drug.
Patients who had a history of allergic reaction to penicillin, may be sensitive to cephalosporin antibiotics.
During treatment, the possibility of false-positive direct Coombs’ test and false-positive reaction of urine for glucose and ketone bodies. False-positive reaction of urine for ketones can be observed when using the test with nitroprusside, but not when using masteron 100 tests nitroferritsianidom. False-positive urine glucose rёaktsiya during the treatment may occur with the use of solutions or Benedict Fehlinga. It is preferable to conduct tests based on the enzyme reaction with glucose oxidase.
Powder for oral suspension 100 mg / 5 ml. 25 g of powder for the preparation of 50 ml of suspension was placed in a bottle of high-density polyethylene with a polypropylene cap with safety lock from children and gasket of laminated aluminum foil «LUPIN» inscription. On the cover indicate in English: «CLOSE TIGHTLY» (ie, close tightly), “TO OPEN» (ie open), «PUSH DOWN AND UNSCREW» ( ie tap and unscrew). On the bottle label is glued with an arrow indicating the level of added water. One vial is placed in a cardboard box with instructions for use.
2 years (powder).
14 days (for the ready slurry).
Do not use after the expiration date printed on the package.
In a dry place at temperatures no higher than 25 ° C.
Keep out of reach of children.