Imide is antifungal broad-spectrum topical. Antifungal effect of the active active substance clotrimazole (imidazole derivative) is connected masteron dosage with the violation of the synthesis of ergosterol, a component of the cell membrane of fungi that alters the permeability of the membrane and causes a subsequent cell lysis. In low concentrations fungistatic effect and in large – fungicide, and not only on the cell profiling. The fungicidal concentrations interacts with mitochondrial and peroxidase enzymes, resulting in an increase in hydrogen peroxide concentration to toxic levels, which also contributes to the destruction of the fungal cells.It is effective against dermatophytes, yeast and molds, as well as the causative agent of multi-colored lichen masteron dosage Pityriasis versicolor (Malazessia furfur) and the pathogen erythrasma. Has antimicrobial activity against Gram-positive (staphylococci, streptococci) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis.
- Genital infections caused by yeast fungi of the genus Candida and / or Trichomonas vaginalis (vulvovaginal candidiasis, trichomoniasis);
- genital superinfection caused by microorganisms sensitive to clotrimazole;
- reorganization of the birth canal before delivery.
: Hypersensitivity to clotrimazole or excipients, I trimester of pregnancy. Avoid the use of pills during menstruation
Be wary – lactation.
Use during pregnancy and lactation
In clinical and experimental studies, it was found that the use of the drug during pregnancy or during breast-feeding has a negative impact on the health of the woman or the fetus (child). However, the question of the advisability of the appointment of the drug should be decided individually after consulting a doctor.
Dosing and Administration
Only for intravaginal use.
Vaginal tablets of 100 mg administered in the evening in the vagina, as far as possible, in the supine position with slightly bent legs, for 6 days. Repeated treatment is possible after consulting a doctor.
itching, burning and swelling of the vaginal mucosa, vaginal discharge, headache, gastralgia, frequent urination masteron dosage, intercurrent cystitis, burning sensation in the penis in sexual partner, pain during sexual intercourse.
Use of the drug in high doses does not cause any reactions and conditions, life-threatening.
In the event of an unintended use of the drug (oral), the following symptoms: anorexia, nausea, vomiting, gastralgia, abnormal liver function; rarely – drowsiness, hallucinations, pollakiuria, skin allergic reactions.
No specific antidote. It should be given by mouth activated charcoal. If necessary – symptomatic treatment.
Interaction with other drugs
When clotrimazole vaginal administration reduces the activity of amphotericin B, and other polyene antibiotics. While the use of nystatin, clotrimazole activity may decrease.
must be simultaneous treatment of sexual partners to prevent urogenital reinfection. Trichomoniasis for a successful treatment in conjunction with other IMIDILom be applied drugs having systemic effect (e.g., metronidazole orally). When simultaneous infection of the labia and the surrounding areas (candida vulvitis) should be further carried out by local drug treatment imide cream.
During pregnancy, vaginal tablets treatment should be carried out without an applicator. Patients with hepatic insufficiency should periodically monitor liver function. When you see signs of hypersensitivity or irritation of the treatment is stopped. If there is no effect for 4 weeks should confirm the diagnosis.
On 6 tablets in aluminum strip. A strip with a tool for intravaginal use (applicator) and instructions for use in a cardboard box.
Do not use after the expiration date.
The temperature is not above 25 ° C, protected masteron dosage from light and out of reach of children.