The action of isosorbide dinitrate can be due to relaxation of vascular smooth muscle cells in the veins, arteries and arterioles. Postcapillary vessels and major arteries relax to a greater extent than the small arterioles. Dilation of postcapillary vascular bed leads to venous blood depositary that, in turn, decreases venous return to the heart. As a result, filling pressure and left masteron hair loss ventricular wall stress decreased (decrease in preload) and decreases myocardial energy and oxygen.Decreased cardiac filling pressure and reduced wall stress contribute to an increase in capillary blood flow and opening previously sealed intramural coronary vessels, as well as improving the supply of oxygen ischemic subendocardial area. Dilation precapillary vessels leads to a decrease in systolic aortic pressure and peripheral vascular resistance (load reduction). Consequently, the reduced left ventricular cardiac output and myocardial oxygen demand. In heart failure, myocardial oxygen demand to additionally increase due to an increase in cardiac output. Direct koranarnyh dilation of blood vessels and eccentric coronary stenosis, as well as a slight decrease in coronary vascular resistance causes improved myocardial perfusion, leading to improved myocardial oxygen supply. A “symptom steal” independent even from a slight decrease in coronary vascular resistance, not shown.
Izoket retard should not be administered in cases of:
- acute myocardial infarction;
- in all cases, reduce cardiac filling pressure, acute circulatory failure (shock, circulatory collapse);
- severe hypotension (systolic blood pressure below 90 mm Hg. Art.).
Early treatment with masteron hair loss nitrates may appear headache, but experience shows that usually after a few days, with incessant taking the drug, it passes. Lowering blood pressure, sleepiness, and increased heart rate may occur during the first days of treatment. Other possible side effects may be nausea, vomiting, erythema (redness). If during treatment the patient takes alcohol can worsen the side effects and reduced therapeutic effect of the drug.
Interactions with other drugs:
The antihypertensive effect Izoket retard may potentiate the simultaneous use of other vasodilators, antihypertensive agents, calcium antagonists, cyclic antidepressants, monoamine oxidase inhibitors and alcohol. When concomitant administration of isosorbide dinitrate and dihydroergotamine, the last level in the blood can increase, leading to a strengthening of its hypotensive action.
DOSAGE AND ADMINISTRATION:
When administered orally, the dosage depends largely on the stage of the disease and the individual requirements in nitrates. With long-term treatment and the absence of other regulations recommend the following dosage:
- Izoket retard 20 – 2-3: 1 tablet per day;
- Izoket retard 40 – 2 x 1 tablet per day;
- Izoket retard 60 – 1 tablet per day or 2 times 1 tablet a day;
- Izoket retard 120 – 1 capsule per day (preferably in the morning).
Izoket retard should be taken after meals, with liquid squeezed small amount of liquid.
When assigning more than one pill a day, the second tablet can be taken only 8 hours after the first to ensure the full effect of the drug (prevention of nitrate tolerance).
It is necessary to select a dose according to the individual needs of the patient in consultation with a physician. Symptoms of vascular collapse may occur after the first dose in patients with labile circulation.It may also be nitrate headache. The masteron hair loss appearance of both symptoms can be avoided if you start receiving treatment with half a tablet twice a day, t. E. With the lowest recommended dose.
The drug should not be taken in the first three months of pregnancy without a doctor’s recommendation.
- Izoket not suitable for the treatment of acute attacks of angina.
- Keep Izoket retard at a temperature no higher than 25 ° C.
- The drug should not be used beyond the expiration date.
Store this medication out of reach of children!
PACKAGING AND PACKING:
- Izoket retard 20, 40 or 60 – packing 20, 50 and 100 tablets.
- Izoket retard 120 – packing 20, 50 and 100 capsules.
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