Active forms of vitamin A, which masteron has a regulatory effect on the growth of epithelial cells and their differentiation. It inhibits terminal differentiation of sebocytes and hyperproliferation of epithelium of the excretory ducts of the sebaceous glands, normalizes the composition of their secretion and facilitates its evacuation. This reduces the production of sebum and reduces the inflammatory reaction around the glands. Isotretinoin influences komedonogenez, inhibits follicular keratinization, suppresses acne caused Propionebacterium. Isotretinoin has anti-seborrhoeic, anti-inflammatory, keratolytic action.Erythromycin is a macrolide antibiotic of the group have an inhibitory effect on protein synthesis in bacteria by reversibly binding ribosomal subgroups. In the treatment of acne erythromycin efficiency manifested in the reduction of the population Propionebacterium acne.Isotretinoin is a component effective in comedonal acne izotreksina phase of the disease, whereas erythromycin is effective in treating acne inflammation or mild to moderate severity.
Percutaneous absorption of isotretinoin and erythromycin insignificant. During the study of the local absorption izotreksina two components in the treatment of patients suffering from acne, it noted only a slight increase of isotretinoin levels compared to baseline levels (isotretinoin is usually determined in the blood plasma). Performance remained below 5 ng / ml and did not grow in the presence of erythromycin. The levels of erythromycin were not detected in the blood plasma. |
Pregnancy and lactation
Application izotreksina when planned and established pregnancy is contraindicated. Percutaneous absorption of isotretinoin is negligible. However, due to the fact that it is unknown whether izotreksin stands out with mother’s milk, izotreksin should not be used during breastfeeding.
Dosing and Administration
The drug is applied thinly to the masteron affected area 2 times a day (in the morning before applying makeup and evening after washing).
The patient should be informed that in some cases to achieve a complete therapeutic effect may need six to eight weeks of treatment.
Izotreksin may cause a slight tingling sensation, burning sensation and irritation, as well as erythema and desquamation of the skin at the site of application of the drug. Photosensitivity.
Accidental overdose izotreksina masteron unlikely due to the nature of the local application of the drug.
Interaction with other drugs
Not recommended simultaneous use of other drugs with keratolytic or exfoliative properties, including the group of retinoids. The drug is reduced with concomitant administration of tetracyclines, as well as local application of glucocorticoids.
Avoid contact with mucous membranes of the mouth, nose and eyes, as well as damaged or ulcerated skin surfaces. Application of medication to sensitive areas of the skin (around the eyes and neck) should be performed with caution. Due to the fact that izotreksin may cause increased sensitivity to sunlight, deliberate masteron or prolonged exposure to the sun should be kept to a minimum.
When side effects which typically occur at 1-2 weeks of treatment should be interrupted for a few days of treatment and resume the drug after irritation symptoms disappear. If side effects persist, treatment should be discontinued.
Gel for topical application.
For 6 g, 25 g, 30 g, 40 g, 50 g aluminum tubes. Each tube together with instructions for use in a stack of cardboard.
Store at temperatures not above 25 ° C. Keep out of the reach of children.
Do not use after the expiration date printed on the package.
Conditions of supply of pharmacies