Posted on08/24/2016 in Articles
masteron (2)

At very low concentrations found in the walls of the gastrointestinal tract.
Penetrates through the placental barrier in small amounts determined in breast milk. The volume of distribution. Malaria: treatment of acute attacks and the vast majority of malaria masterone therapy, caused by Plasmodium vivax, Plasmodium ovale and Plasmodium malariae (except hydroxychloroquine-resistant cases) and susceptible strains of Plasmodium falciparum; radical treatment of malaria caused by susceptible strains of Plasmodium falciparum; rheumatoid arthritis; lupus ; fotodermatit; asthma, Sjögren’s syndrome.Hypersensitivity to the drug, pregnancy, lactation, children under 3 years, as well as long-term therapy in children. Precautions – retinopathy (maculopathy including history), violation of bone marrow blood, diseases of the central nervous system and cardiovascular system, psychosis (including history), porphyria, psoriasis, deficiency of glucose-6-phosphate dehydrogenase, liver and / or kidney failure.

Dosage and administration
: Inside, during a meal or drinking a glass of milk. 200 mg of hydroxychloroquine sulfate equivalent to 155 mg of hydroxychloroquine base.
Rheumatoid arthritis:. Initial masterone dose for adults – 400-600 mg / day maintenance -200-400 mg /
Juvenile arthritis: dose should not exceed 6.5 mg / kg or 400 mg / day (choose the lowest dose).
Discoid and systemic lupus erythematosus:. initial dose for adults – 400-800 mg / day maintenance – 200-400 mg / day
Photo dermatosis: up to 400 mg / day. Treatment should be limited to periods of maximum solar exposure.
Malaria: suppressive therapy in adults – 400 mg / day every day 7; children weekly overwhelming dose – 6.5 mg / kg, but regardless of body weight must not exceed the dose for adults (400 mg). If conditions permit, suppressive therapy is prescribed for 2 weeks before exposure, otherwise, you can assign the initial double dose: 800 mg – adults and 12.9 mg / kg (but not exceeding 800 mg) – the children, dividing into 2 doses with an interval of 6 . h suppressive therapy should be continued for 8 weeks.
After leaving the endemic area.
Treatment of acute attacks of malaria: the initial dose for adults – 800 mg, then 6-8 hours – 400 mg and 400 mg on days 2 and 3 treatment (a total of 2 g of hydroxychloroquine sulfate). . As an alternative method may be an effective dose of 800 mg once daily
for children total dose – 32 mg / kg (but not exceeding 2 g) was assigned for 3 days: the first dose – 12.9 mg / kg (but not exceeding a single dose of 800 mg) The second dose – 6.5 mg / kg (not to exceed 400 mg) after 6 hr after the first, the third dose – 6.5 mg / kg (not to exceed 400 mg) 18 hours after the second dose, the fourth dose – 6.5 mg / kg ( but not exceeding 400 mg) at 24 hours after the third dose.
the dose for adults may be calculated for 1 kg body weight, as well as for children.

Side effects : the part of the musculoskeletal and nervous systems : weight loss, myopathy or neyromiopatiya leading to increasing myasthenia and atrophy of proximal muscle groups; sensory disturbances, reduced tendon reflexes, abnormal nerve conduction; headache, dizziness, nervousness, psychosis, emotional instability, seizures. From the senses : tinnitus, hearing loss, photophobia, disturbance in visual acuity, disturbance of accommodation, swelling and clouding of the cornea, scotoma; long-term use of large doses – retinopathy (including a violation of pigmentation and visual field defects), optic atrophy, keratopathy, dysfunction of the ciliary muscles. Cardio-vascular system : long masterone-term therapy with high doses of -miokardiodistrofiya, cardiomyopathy, atrioventricular blockade, reduced myocardial contractility, myocardial hypertrophy. From the digestive system : nausea, vomiting (rarely), loss of appetite, abdominal pain, spastic nature, diarrhea; hepatotoxicity (liver dysfunction, liver failure). From the side of hematopoiesis : neutropenia, aplastic anemia, agranulocytosis, thrombocytopenia, hemolytic anemia (a deficiency in patients with glucose-6-phosphate dehydrogenase). For the skin : skin rash (incl . bullous and generalized pustular), itching, violation of skin pigmentation and mucous membranes, bleaching of hair, alopecia, photosensitivity, Stevens-Johnson syndrome (erythema mnogomofornaya), exacerbation of psoriasis (including fever and hyperskeocytosis), exacerbation of porphyria.

Before and during therapy should be carried out at least 1 time in 6 months ophthalmologic examination.
During therapy requires constant monitoring of blood cell composition, the state of skeletal muscle (including tendon reflexes).
During treatment, care should be taken when driving and other lesson. potentially hazardous activities that require high concentration and psychomotor speed reactions.

Overdose Symptoms : cardiotoxicity (conductivity violation along the beam branch block; in chronic intoxication – myocardial hypertrophy of both ventricles), lower blood pressure, neurotoxicity (dizziness, headache, irritability, convulsions, coma), blurred vision, respiratory arrest and cardiac arrest. Overdose especially dangerous in young children, even reception 1-2 g of the drug can be fatal. Treatment : gastric lavage, the appointment of activated carbon (at a dose 5 times higher than the dose), forced diuresis and alkalinization of urine (such as ammonium chloride to a pH of urine – 5.5-6.5) increase the urinary excretion of 4-aminoquinoline, symptomatic therapy (including the appointment in convulsions -diazepam, antishock therapy). Necessary to control the concentration of sodium in the blood serum and constant medical supervision for at least 6 hours after symptom relief.

Patient interaction
Increases concentration of digoxin in plasma, aminoglycosides enhance the blocking effect on the neuromuscular conductivity. It enhances the effect of hypoglycemic drugs (requires a dose reduction of the latter). With simultaneous use of antacids the interval between the reception must be at least 4 hours (absorption decrease). Alkaline water and alkaline accelerate excretion. Increases plasma concentration of penicillamine, and the risk of its side effects of the blood, urinary tract, and skin reactions. Increases side effects of glucocorticoids, salicylates, anti-arrhythmic drugs class 1a, hematologic, hepato- and neurotoxic agents.

Product form
The tablets covered with a foil wrapper 200 mg.
10 tablets in blister Al / PVC.
At 1, 2, 3 or 6 blisters with instruction on use are placed in a cardboard box.

Shelf life
2 years. At the end of the shelf life of the masterone drug can not be used.

Storage conditions
List B.
Store in a dry, dark place at a temperature no higher than 25 ° C.
Keep out of reach of children.

Conditions of supply of pharmacies
on medical prescription. steroiden kaufen

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